Cerebellum as part of a network: development

Themes to address (and original research articles)

Background on how the cerebellum develops

  • Sival, D. A., van Noort, S. A., Tijssen, M. A., de Koning, T. J., & Verbeek, D. S. (2022). Developmental neurobiology of cerebellar and Basal Ganglia connections. European Journal of Paediatric Neurology, 36, 123-129
  • De Benedictis, A., Rossi-Espagnet, M. C., de Palma, L., Carai, A., & Marras, C. E. (2022). Networking of the human cerebellum: From anatomo-functional development to neurosurgical implications. Frontiers in Neurology, 13, 120.
  • Voogd, J. (2023). The development of the cerebellum: from the beginnings. In Development of the cerebellum from molecular aspects to diseases (pp. 1-32). Cham: Springer International Publishing.
  • Chudley, A. E. (2023). Teratogenic Influences on Cerebellar Development. Development of the Cerebellum from Molecular Aspects to Diseases, 363-388.
  • Silbereis, J. C., Pochareddy, S., Zhu, Y., Li, M., & Sestan, N. (2016). The cellular and molecular landscapes of the developing human central nervous system. Neuron, 89(2), 248-268.
  • Stoessel, M. B., & Majewska, A. K. (2021). Little cells of the little brain: microglia in cerebellar development and function. Trends in neurosciences, 44(7), 564-578. Background on cerebellum and transcriptomics
  • Haldipur, P., Millen, K. J., & Aldinger, K. A. (2022). Human cerebellar development and transcriptomics: implications for neurodevelopmental disorders. Annual Review of Neuroscience, 45, 515-531.

Background on cerebellum and abnormal social development

  • Gibson, J. M., Howland, C. P., Ren, C., Howland, C., Vernino, A., & Tsai, P. T. (2022). A critical period for development of cerebellar-mediated autism-relevant social behavior. Journal of Neuroscience, 42(13), 2804-2823.
  • Hadders‐Algra, M. (2022). Emerging signs of autism spectrum disorder in infancy: Putative neural substrate. Developmental Medicine & Child Neurology, 64(11), 1344-1350. Bylemans, T., Heleven, E., Baetens, K., Deroost, N., Baeken, C., & Van Overwalle, F. (2023). Mentalizing and narrative coherence in autistic adults: Cerebellar sequencing and prediction. Neuroscience & Biobehavioral Reviews, 105045.
  • Olson, I. R., Hoffman, L. J., Jobson, K. R., Popal, H. S., & Wang, Y. (2023). Little brain, little minds: The big role of the cerebellum in social development. Developmental Cognitive Neuroscience, 101238.

Transcriptomics shape cerebellar development (and later psychiatric conditions)

  • Haldipur, P., Millen, K. J., & Aldinger, K. A. (2022). Human cerebellar development and transcriptomics: implications for neurodevelopmental disorders. Annual Review of Neuroscience, 45, 515-531.
  • Aldinger, K. A., Thomson, Z., Phelps, I. G., Haldipur, P., Deng, M., Timms, A. E., … & Millen, K. J. (2021). Spatial and cell type transcriptional landscape of human cerebellar development. Nature neuroscience, 24(8), 1163-1175.

Prenatal sensitive period of cerebellar development

  • Hughes, D. E., Kunitoki, K., Elyounssi, S., Luo, M., Bazer, O. M., Hopkinson, C. E., … & Roffman, J. L. (2023). Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development. Nature Neuroscience, 1-11
  • Enogieru, A. B., & Momodu, O. I. (2021). The developing cerebellum as a target for toxic substances: protective role of antioxidants. The Cerebellum, 1-17.
  • Vacher, C. M., Lacaille, H., O’Reilly, J. J., Salzbank, J., Bakalar, D., Sebaoui, S., … & Penn, A. A. (2021). Placental endocrine function shapes cerebellar development and social behavior. Nature Neuroscience, 24(10), 1392-1401.
  • McCarthy, M. M. (2021). Placental signaling influences cerebellum development. Nature Neuroscience, 24(10), 1343-1345.
  • Van Den Heuvel, M. I., Hect, J. L., Smarr, B. L., Qawasmeh, T., Kriegsfeld, L. J., Barcelona, J., … & Thomason, M. E. (2021). Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth. Scientific reports, 11(1), 2228.
  • Barcelona, J., … & Thomason, M. E. (2021). Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth. Scientific reports, 11(1), 2228.
  • Spoto, G., Amore, G., Vetri, L., Quatrosi, G., Cafeo, A., Gitto, E., … & Di Rosa, G. (2021). Cerebellum and prematurity: a complex interplay between disruptive and dysmaturational events. Frontiers in Systems Neuroscience, 15, 655164.
  • Lubczyńska, M. J., Muetzel, R. L., El Marroun, H., Hoek, G., Kooter, I. M., Thomson, E. M., … & Guxens, M. (2021). Air pollution exposure during pregnancy and childhood and brain morphology in preadolescents. Environmental Research, 198, 110446.

Cortico-cerebellar connectivity and why cerebellum may be an important locus in neurodevelopmental disorders

  • King, M., Shahshahani, L., Ivry, R. B., & Diedrichsen, J. (2023). A task-general connectivity model reveals variation in convergence of cortical inputs to functional regions of the cerebellum. Elife, 12, e81511.
  • Shahshahani, L., King, M., Nettekoven, C., Ivry, R., & Diedrichsen, J. (2023). Selective recruitment: Evidence for task-dependent gating of inputs to the cerebellum. bioRxiv, 2023-01.
  • Müller, E. J., Palesi, F., Hou, K. Y., Tan, J., Close, T., Wheeler-Kingschott, C. A., … & Shine, J. M. (2022). Parallel processing relies on a distributed, low-dimensional cortico-cerebellar architecture. Network Neuroscience, 1-41.

Social cerebellum and (abnormal)development

  • Okada, N. J., Liu, J., Tsang, T., Nosco, E., McDonald, N. M., Cummings, K. K., … & Dapretto, M. (2022). Atypical cerebellar functional connectivity at 9 months of age predicts delayed socio‐communicative profiles in infants at high and low risk for autism. Journal of Child Psychology and Psychiatry, 63(9), 1002-1016.
  • Siciliano, L., Olivito, G., Lupo, M., Urbini, N., Gragnani, A., Saettoni, M., … & Leggio, M. (2023). The role of the cerebellum in sequencing and predicting social and non-social events in patients with bipolar disorder. Frontiers in Cellular Neuroscience, 17.
  • van der Heijden, M. E., Gill, J. S., & Sillitoe, R. V. (2021). Abnormal cerebellar development in autism spectrum disorders. Developmental neuroscience, 43(3-4), 181-190.
  • King, M., Bruinsma, S., & Ivry, R. B. (2022). No evidence for semantic prediction deficits in individuals with cerebellar degeneration. Neurobiology of Language, 1-29

Papers of special or outstanding interest:

  • Van Den Heuvel, M. I., Hect, J. L., Smarr, B. L., Qawasmeh, T., Kriegsfeld, L. J., Barcelona, J., … & Thomason, M. E. (2021). Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth. Scientific reports, 11(1), 2228.
  • Hughes, D. E., Kunitoki, K., Elyounssi, S., Luo, M., Bazer, O. M., Hopkinson, C. E., … & Roffman, J. L. (2023). Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development. Nature Neuroscience, 1-11
  • Vacher, C. M., Lacaille, H., O’Reilly, J. J., Salzbank, J., Bakalar, D., Sebaoui, S., … & Penn, A. A. (2021). Placental endocrine function shapes cerebellar development and social behavior. Nature Neuroscience, 24(10), 1392-1401.
  • Aldinger, K. A., Thomson, Z., Phelps, I. G., Haldipur, P., Deng, M., Timms, A. E., … & Millen, K. J. (2021). Spatial and cell type transcriptional landscape of human cerebellar development. Nature neuroscience, 24(8), 1163-1175.
  • Okada, N. J., Liu, J., Tsang, T., Nosco, E., McDonald, N. M., Cummings, K. K., … & Dapretto, M. (2022). Atypical cerebellar functional connectivity at 9 months of age predicts delayed socio‐communicative profiles in infants at high and low risk for autism. Journal of Child Psychology and Psychiatry, 63(9), 1002-1016.