Atypical FC patterns in PDE (prenatal drug exposure)
- Neonate brain connectivity is disrupted by PDE
- Distinct and widespread regions differentially affected by timing
- neonatal connectivity predicts 12-month behavioral outcome
- early differences may alter trajectories of neonatal brain function over first year of life
- examining the timing of environmental factors provides insight into risk and resilience
- multimodal integration of brain-based measures is necssary
Braincharting autism and ADHD reveals age- and sex specific effects
- Saashi Bedford, PhD - University of Cambridge
- ASD: patterns of altered brain development
- Normative modeling: model relationhip between two variables in a typically development sample (e.g., pediatric growth charts)
- models must account for age / sex / scanner / site differences
- check bethlemen et al. (2022) brain growth chart work
- data: ABIDE, HBN, MRC etc. lifespan brain chart consortium
- ASD: more localized changes, ADHD: more distributed
- combined ASD + ADHD: distributed and stronger efects
- sex differences: sex x diagnosis interaction for ASD but not ADHD. localized to insula.
- how do these groups change across development?
- intervals of 4 years, sliding by one year
- early brain overgrowth in ASD reflected in mean CT spike early in life
Disrupted structural connectivity-gray matter covariance coupling and associated transcriptomics in ADHD